Search results for "transdermal fentanyl"

showing 4 items of 4 documents

Opioid Plasma Concentrations during a Switch from Transdermal Fentanyl to Methadone

2007

Opioid switching is often used to improve the opioid response in patients with cancer experiencing poor analgesia or adverse effects. When switching between drugs with delayed effect because of pharmacokinetics or type of delivery, concerns exist about the correct timing of introducing the second drug after stopping the previous one. The aim of this study was to assess plasmatic changes of fentanyl and methadone underlying the clinical events occurring during opioid switching. Eighteen patients with cancer receiving transdermal fentanyl with uncontrolled pain and/or moderate to severe opioid adverse effects, were switched to oral methadone using an initial fixed ratio of 1:20. Fentanyl patc…

AdultMaleTime FactorsPalliative careAdministration Cutaneousmethadone.Drug Administration ScheduleFentanylPharmacokineticsNeoplasmsHumansMedicineAdverse effectGeneral NursingAgedPain MeasurementTransdermalbusiness.industrywitchingPalliative CareOpioid plasma concentrationGeneral MedicineMiddle Agedtransdermal fentanylPain IntractableAnalgesics OpioidFentanylTreatment OutcomeAnesthesiology and Pain MedicineOpioidBasal (medicine)AnesthesiaFemalebusinessMethadonemedicine.drugMethadoneJournal of Palliative Medicine
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Rapid Switching Between Transdermal Fentanyl and Methadone in Cancer Patients

2005

Purpose The aim of this study was to examine the clinical effects of switching from transdermal (TTS) fentanyl to methadone, or vice versa, in patients with a poor response to the previous opioid. Patients and Methods A prospective study was carried out on 31 patients who switched from TTS fentanyl to oral methadone, or vice versa, because of poor opioid response. A fixed conversion ratio of fentanyl to methadone of 1:20 was started and assisted by rescue doses of opioids, and then doses were changed according to clinical response. Pain and symptom intensity, expressed as distress score, were recorded before switching doses of the two opioids and after subsequent doses. The number of change…

Malecancer patientCancer ResearchPaincancer patients; rapid switching; transdermal fentanyl; methadone; prospective studyAdministration CutaneousFentanylNeoplasmsmedicineHumansIn patientProspective StudiesProspective cohort studyPain MeasurementTransdermalbusiness.industryCancerMiddle Agedmedicine.diseasetransdermal fentanylAnalgesics OpioidFentanylClinical trialrapid switchingTreatment OutcomeOncologyOpioidAnesthesiaFemalebusinessMethadoneprospective studymedicine.drugMethadoneJournal of Clinical Oncology
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Switching from Transdermal Drugs: An Observational "N of 1" Study of Fentanyl and Buprenorphine

2007

The aim of this study was to confirm that the concomitant presence of transdermal fentanyl (TTS FE) and buprenorphine (TTS BU) may be feasible without important consequences, using doses presumed to be equianalgesic. A prospective "N of 1" study was carried out in a sample of volunteers with cancer pain receiving stable doses of TTS FE or TTS BU, with adequate pain and symptom control. In the study design, each patient provided data before and after a switch from one opioid to the other and then back to the previous one. Sixteen patients receiving daily stable doses of 0.6 or 1.2 mg of TTS FE were switched to TTS BU using an FE-BU ratio of 0.6-0.8. After three days, the TTS BU patch was rem…

OralAdultMaletransdermal buprenorphinePainAdministration OralOpioidAdministration CutaneousFentanylopioid switchingNeoplasmsMedicineHumansDosingProspective StudiesCancer painNursing (all)2901 Nursing (miscellaneous)General NursingTransdermalAgedPain MeasurementIntractableAnalgesicsbusiness.industryMiddle AgedEquianalgesictransdermal fentanylBuprenorphinePain IntractableAnalgesics OpioidFentanylCutaneousAnesthesiology and Pain MedicineNeurologyOpioidConcomitantAnesthesiaCancer pain; opioid switching; transdermal buprenorphine; transdermal fentanyl; Administration Oral; Adult; Aged; Analgesics Opioid; Buprenorphine; Female; Fentanyl; Humans; Male; Middle Aged; Neoplasms; Pain Measurement; Pain Intractable; Prospective Studies; Administration Cutaneous; Anesthesiology and Pain Medicine; Neurology (clinical); Neurology; Nursing (all)2901 Nursing (miscellaneous)AdministrationFemaleNeurology (clinical)businessCancer painmedicine.drugBuprenorphine
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World Health Organization guidelines for cancer pain: a reappraisal

2005

Pain is a prevalent symptom experienced by at least 30% ofpatients undergoing an oncological treatment for metastaticdisease and by more than 70% of advanced cancer patients[1]. In 1986 the World Health Organization [2] published a setof guidelines for cancer pain management based on the three-step analgesic ladder [2]. The main aim of WHO guidelienswas to legitimize the prescribing of strong opioids, arisingfrom evidence of poor management of cancer pain, due toreluctance of health care professionals, institutions, and gov-ernment to use opioids because of fears of addition, toleranceand illegal abuse.Its application is reported to achieve satisfactory pain reliefin up to 90% of patients w…

medicine.medical_specialtyAlternative medicinePain reliefPainWorld Health OrganizationWorld healthAdrenal Cortex HormonesNeoplasmsHealth caremedicineHumansIntensive care medicineHigh rateAnalgesicsMorphinebusiness.industryBreakthrough PainSmall sampleHematologytransdermal fentanylAnalgesics OpioidOncologyOpioidAnesthesiaPractice Guidelines as TopicbusinessCancer painmedicine.drugAnnals of Oncology
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